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KMID : 0648320030090020125
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Journal of The Korean Society of Hypertension
2003 Volume.9 No. 2 p.125 ~ p.132
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Effects of Irbesartan on Aortic Stiffness in Hypertensive Patients
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Ahn Jung-Chun
Park Chang-Gyu
Lim Hong-Euy
Park Sung-Mi
Shin Sung-Hee
Lee Seung-Jin
Kim Eung-Ju
Seo Hong-Seog
Oh Dong-Ju
Ro Young-Moo
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Abstract
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Background: Increased pulse wave velocity (PWV), representing aortic stiffness, and left ventricular
hypertrophy (LVH) are independent risk factors of cardiovascular events in hypertensive patients. We have
conducted a prospective study to examine the effects of angiotensin II receptor anatagonist (Irbesartan)
on PWV and LVH in hypertensive patients.
Methods: A total of 52 patients (age: 53.3±8.0 yrs) who had never been treated for hypertension were
studied and had no evidence of associated cardiovascular disease. Blood pressure, heart rate, aortic PWV
and left ventricular mass index (LVMI) by 2-D echocardiograpy were measured at baseline and after
irbesartan therapy (150 mg or 300 mg/day) at 12 weeks and 24 weeks.
Results: After 12 weeks, blood pressure decreased compared to baseline (SBP: 163.7±13.8 mmHg vs
134.6±13.3 mmHg, p<0.001, DBP: 102.4±9.6 mmHg vs 86.0±10 mmHg, p<0.001), without significant
difference of heart rate at 12 and 24 weeks. Aortic PWV after Irbesartan treatment significantly decreased
from 9.6±2.9 m/sec to 8.73 m/sec at 12 weeks (p=0.064) and to 7.7±2.1 m/sec at 24 weeks (p=0.007).
LVMI had no significant change at both 12 and 24 weeks after treatment (from 88.9±21.7 g/m2 to 90.8±
23.2 g/m2 at 12 weeks and 86.9±23.5 g/m2 at 24 weeks).
Conclusions: Mid-term (24week) treatment of angiotenin II antagonist (Irbesartan) can improve aortic
stiffness, but not LVMI in hypertensive patients.
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KEYWORD
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Hypertension, Angiotensin receptor blocker, Aortic stiffness, PWV
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